Department of Pharmacology, School of Pharmaceutical Sciences, 12517Capital Medical University, Beijing, China.
School of Basic Medical Sciences, 12517Capital Medical University, Beijing, China.
J Biomater Appl. 2022 Sep;37(3):493-501. doi: 10.1177/08853282221102673. Epub 2022 May 15.
Myocardial infarction (MI) is a major cause of death worldwide. Early and precise diagnosis of myocardial viability after MI is extremely important for effective treatment and prognosis evaluation. Herein, we developed the BSA-templated manganese carbonate (MnCO@BSA) nanoparticles as an MR imaging contrast agent for accurate detection of the infarcted regions. The chemophysical features, targeting capability toward the infarct, and biocompatibility were evaluated. The nanoparticles showed superior chemical stability. study suggested that the MnCO@BSA nanoparticles do not enter normal cardiomyocytes. MR imaging indicated that the MnCO@BSA with a high longitudinal () relaxivity of 5.84 mMs at physiological condition specifically accumulated into the infarcted regions of myocardial ischemia/reperfusion (I/R) mice. In addition, the MnCO@BSA nanoparticles exhibited low cytotoxicity to cardiomyocytes, no damage to organs and good hemocompatibility. Thereby, the MnCO@BSA nanoparticles manifested great potential as an extracellular contrast agent of MR imaging for sensitive and specific detection of the infarcted regions during acute myocardial I/R injury.
心肌梗死（MI）是全球范围内主要的死亡原因。MI 后心肌存活的早期和准确诊断对有效治疗和预后评估极为重要。在此，我们开发了 BSA 模板化的碳酸锰（MnCO@BSA）纳米粒子作为磁共振成像对比剂，用于准确检测梗死区域。评估了其理化特性、对梗死的靶向能力和生物相容性。研究表明，MnCO@BSA 纳米粒子不会进入正常心肌细胞。磁共振成像表明，MnCO@BSA 在生理条件下具有高纵向弛豫率（）5.84 mMs，可特异性地积聚到心肌缺血/再灌注（I/R）小鼠的梗死区域。此外，MnCO@BSA 纳米粒子对心肌细胞表现出低细胞毒性，对器官无损伤且具有良好的血液相容性。因此，MnCO@BSA 纳米粒子作为磁共振成像的细胞外对比剂，具有用于急性心肌 I/R 损伤时敏感且特异性地检测梗死区域的巨大潜力。
