雷尼替丁（一种特异性H2受体拮抗剂）的抗炎特性。
Anti-inflammatory property of ranitidine, a specific H2-receptor antagonist.
作者信息
Patwardhan M D, Muley M P, Manekar M S
出版信息
Indian J Physiol Pharmacol. 1986 Jul-Sep;30(3):205-9.
PMID:3557609
Abstract
The effects of ranitidine (2 mg/kg, po) and phenylbutazone (100 mg/kg po) have been studied in different models of acute and chronic inflammation in rats. Ranitidine showed significant anti-inflammatory activity in the four models used. This observation supports the concept that histamine has a pro-inflammatory role that is mediated via stimulation of H2-receptors.
摘要
已在大鼠急性和慢性炎症的不同模型中研究了雷尼替丁（2毫克/千克，口服）和保泰松（100毫克/千克，口服）的作用。雷尼替丁在所使用的四种模型中均显示出显著的抗炎活性。这一观察结果支持了组胺具有通过刺激H2受体介导的促炎作用这一概念。
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