State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China.
J Agric Food Chem. 2022 May 25;70(20):6015-6025. doi: 10.1021/acs.jafc.2c00773. Epub 2022 May 16.
Currently, there is insufficient viricide to effectively control tomato spotted wilt virus (TSWV). To address this pending issue, a series of thienopyrimidine-containing dithioacetal derivatives were prepared and tested for their anti-TSWV activities. A subsequent three-dimensional quantitative structure-activity relationship was constructed to indicate the development of optimal compound . The obtained compound had excellent anti-TSWV curative, protective, and inactivating activities (63.0, 56.6, and 74.1%, respectively), and the EC values of protective and inactivating activities of compound were 252.8 and 113.5 mg/L, respectively, better than those of ningnanmycin (284.8 and 144.7 mg/L) and xiangcaoliusuobingmi (624.9 and 300.0 mg/L). In addition, the anti-TSWV activity of compound was associated with defense-related enzyme activities, enhanced photosynthesis, and reduced stress response, thereby enhancing disease resistance.
目前，用于有效控制番茄斑萎病毒（TSWV）的杀病毒剂还不够。为了解决这一待解决的问题，合成了一系列含噻吩嘧啶的二硫缩醛衍生物，并对其抗 TSWV 活性进行了测试。随后构建了三维定量构效关系，以指示最佳化合物的开发。得到的化合物具有优异的抗 TSWV 治疗、保护和失活活性（分别为 63.0%、56.6%和 74.1%），化合物的保护和失活活性的 EC 值分别为 252.8 和 113.5mg/L，优于宁南霉素（284.8 和 144.7mg/L）和香豆素硫冰（624.9 和 300.0mg/L）。此外，化合物的抗 TSWV 活性与防御相关酶活性、增强光合作用和减轻应激反应有关，从而提高了抗病性。
