Children's Hospital, Lahore, Pakistan.
Children's Hospital, Lahore-Pakistan.
J Ayub Med Coll Abbottabad. 2022 Apr-Jun;34(2):300-303. doi: 10.55519/JAMC-02-9324.
Nephrotic syndrome is a clinical syndrome defined by massive proteinuria (greater than 40 mg/m2/hour) responsible for hypoalbuminemia (less than 30 g/L) resulting in oedema and hyperlipidaemia. Objective of the study was to compare the frequency of relapse rate with short and long duration steroid therapy in Nephrotic syndrome. It was a Quasiexperimental control group design, conducted at the Department of Paediatric Nephrology, The Children's Hospital and Institute of Child Health, Lahore. Duration of study: One year.
The data of 150 patients with steroid sensitive nephrotic syndrome was included with clinical presentation and diagnostic investigations. The children were randomly divided into long and short duration steroid treatment groups. Outcome was determined in terms of relapse rate after achieving remission with both treatment strategies. Independent sample t test was applied to compare the outcome in both groups with p≤0.05 considered as significant. Data was stratified for all the effect modifiers like age and gender and poststratification chi square test was applied to see the effect on the outcome, taking p≤0.05 as significant.
The relapse rate of the disease was 0.8±0.72 per year in short-duration group and 1.28±0.61 per year in subjects receiving long-duration steroids, and difference between the two groups was found to be statistically significant (p<0.001). The relapse rate was less in the short duration therapy group as compared to the long duration therapy 62.7% (n=47) patients in group A had one or more relapses of the disease within one year of follow up in contrast to 94.7% (n=71) children in group B (p<0.001).
Patients receiving short duration steroid therapy showed a lower relapse rate as compared to those who were administered long term steroids.
肾病综合征是一种临床综合征，其特征为大量蛋白尿（>40mg/m2/h），导致低白蛋白血症（<30g/L），进而引起水肿和高脂血症。本研究旨在比较短期和长期类固醇治疗肾病综合征的复发率。这是一项准实验对照组设计，在拉合尔儿童医院和儿童健康研究所儿科肾病科进行。研究持续时间为一年。
纳入了 150 名符合类固醇敏感肾病综合征临床表现和诊断标准的患者。这些儿童被随机分为短期和长期类固醇治疗组。两种治疗策略均达到缓解后，根据复发率来确定结局。采用独立样本 t 检验比较两组的结局，p≤0.05 为差异有统计学意义。对所有效应修饰因子（如年龄和性别）进行分层，并应用事后卡方检验来观察其对结局的影响，p≤0.05 为差异有统计学意义。
短期组的疾病复发率为 0.8±0.72/年，长期组为 1.28±0.61/年，两组之间的差异具有统计学意义（p<0.001）。与长期组相比，短期组的复发率较低，在随访的一年内，A 组 62.7%（n=47）的患者出现一次或多次疾病复发，而 B 组 94.7%（n=71）的儿童（p<0.001）。
与长期接受类固醇治疗的患者相比，接受短期类固醇治疗的患者复发率较低。
