From the Department of Soft Tissue Surgery, Willows Veterinary Centre and Referral Service, Solihull, United Kingdom.
J Am Anim Hosp Assoc. 2022 May 1;58(3):152-155. doi: 10.5326/JAAHA-MS-7190.
Obstructive sleep apnea (OSA) has been uncommonly reported in dogs and is often associated with brachycephalic obstructive airway syndrome (BOAS). OSA independent from BOAS has been rarely reported. Treatment of OSA with ondansetron has only been reported in one dog and has not been reported in a breed commonly affected by BOAS. Here, we report the case of a pug with episodes of OSA despite appropriate treatment of BOAS. Administration of ondansetron led to a rapid and near-complete resolution of the clinical signs, with a follow-up of 3 mo. OSA independent of BOAS should be considered as a differential diagnosis in dogs that present for sleep-disordered breathing without exercise intolerance after appropriate treatment for BOAS. Use of certain serotonin antagonists may be useful as a treatment option for these cases.
阻塞性睡眠呼吸暂停（OSA）在犬中罕见报道，常与短头气道阻塞综合征（BOAS）相关。OSA 不伴 BOAS 时则很少见。昂丹司琼治疗 OSA 仅在一只犬中报道过，且在 BOAS 常见的品种中尚未报道。在此，我们报告一例波尔多犬在 BOAS 得到适当治疗后仍出现 OSA 发作。昂丹司琼的给药导致临床症状迅速且几乎完全缓解，随访 3 个月。BOAS 治疗后出现睡眠呼吸障碍而无运动不耐受的犬，应考虑 OSA 不伴 BOAS 作为鉴别诊断。对于这些病例，使用某些 5-羟色胺拮抗剂可能是一种有用的治疗选择。
