From the Oncology Department (S.P.), Toronto Veterinary Emergency and Referral Hospital, Scarborough, Ontario, Canada.
From the Diagnostic Imaging Department (S.M.), Toronto Veterinary Emergency and Referral Hospital, Scarborough, Ontario, Canada.
J Am Anim Hosp Assoc. 2022 May 1;58(3):156-159. doi: 10.5326/JAAHA-MS-7100.
A 9 yr old castrated male miniature schnauzer was diagnosed histopathologically with a mucosal histiocytic sarcoma of the urinary bladder apex, biopsied at the time of surgical cystotomy. Sequential adjuvant chemotherapy, including both lomustine (discontinued because of adverse effects) and then doxorubicin, were employed. A response to both agents was documented. Ultimately, a complete response was achieved following completion of the doxorubicin protocol. A complete response persisted 768 days following diagnosis at last follow-up. Histiocytic sarcoma of the urinary bladder remains a rare diagnosis in veterinary medicine. Only one previous case report is currently published. This case contrasts with the previous case report, which reported a survival of only 2 mo.
一只 9 岁已去势的雄性迷你雪纳瑞，经手术膀胱切开活检，组织病理学诊断为膀胱顶部黏膜组织细胞肉瘤。当时采用了包括洛莫司汀（因不良反应而停用）和多柔比星在内的连续辅助化疗。两种药物均有疗效。在完成多柔比星方案后，最终完全缓解。在最后一次随访时，诊断后 768 天完全缓解仍持续存在。膀胱组织细胞肉瘤在兽医医学中仍是一种罕见的诊断。目前仅发表过一例既往病例报告。本病例与既往病例报告不同，后者报告的存活期仅为 2 个月。
