Labeeuw M, Zech P, Pozet N, Hadj-Aissa A, Traeger J
Int J Clin Pharmacol Ther Toxicol. 1987 Jan;25(1):23-5.
The glomerular filtration rate (GFR, inulin clearance) and renal plasma flow (RPF, PAH clearance) were measured in 35 hypertensive patients during chronic administration of an alpha-beta-blocker, labetalol. No significant changes in GFR occurred but RPF increased significantly. The increase in RPF was positively correlated with the decrease in mean arterial blood pressure. Patients with renal failure showed changes similar to patients with normal renal function. Thus chronic treatment with labetalol, unlike most beta-blockers, can increase RPF, an effect which could be related to the alpha-blocking activity of the drug.
在35例高血压患者长期服用α-β阻滞剂拉贝洛尔期间，测量了肾小球滤过率（GFR，菊粉清除率）和肾血浆流量（RPF，对氨基马尿酸清除率）。GFR无显著变化，但RPF显著增加。RPF的增加与平均动脉血压的降低呈正相关。肾衰竭患者的变化与肾功能正常的患者相似。因此，与大多数β阻滞剂不同，拉贝洛尔长期治疗可增加RPF，这一作用可能与该药物的α阻断活性有关。
