Department of Brain Sciences, Daegu Gyeongbuk Institute of Science Technology (DGIST), Daegu 42988, South Korea.
Department of Brain Sciences, Daegu Gyeongbuk Institute of Science Technology (DGIST), Daegu 42988, South Korea.
Trends Neurosci. 2022 Jul;45(7):517-528. doi: 10.1016/j.tins.2022.04.004. Epub 2022 May 13.
Multiple synaptic adhesion proteins are thought to collectively define the properties of specific synapses and thereby shape the architectures of neural circuits. Growing evidence supports a molecular model in which a set of central hub proteins interacts with a vast number of other proteins to organize multifarious synaptic adhesion pathways. However, several fundamental open questions remain, partly owing to drawbacks in current approaches and interpretations. In this opinion, we provide an overview of synaptic adhesion pathways, underscoring open questions to be addressed in future work, and highlighting approaches for advancing understanding of synaptic adhesion processes.
人们认为，多种突触黏附蛋白共同决定了特定突触的特性，并由此塑造了神经回路的结构。越来越多的证据支持这样一种分子模型，即一组核心枢纽蛋白与大量其他蛋白相互作用，以组织多种多样的突触黏附途径。然而，由于当前方法和解释的局限性，仍存在一些尚未解决的基本问题。在这篇观点文章中，我们概述了突触黏附途径，强调了未来工作中需要解决的问题，并强调了推进突触黏附过程理解的方法。
