WAVE 调节复合物介导线粒体功能的协调作用。

Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization.

机构信息

Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu, 42988, Korea.

Center for Synapse Diversity and Specificity, DGIST, Daegu, 42988, Korea.

出版信息

Exp Mol Med. 2023 Jun;55(6):1065-1075. doi: 10.1038/s12276-023-01004-1. Epub 2023 Jun 1.

DOI:10.1038/s12276-023-01004-1

PMID:37258575

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10318009/

Abstract

The WAVE regulatory complex (WRC), composed of five components-Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300-is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.

摘要

WAVE 调节复合物（WRC）由五个成分组成-Cyfip1/Sra1、WAVE/Scar、Abi、Nap1/Nckap1 和 Brk1/HSPC300-对于真核细胞中适当的肌动蛋白细胞骨架动力学和重塑是必不可少的，可能通过将各种模式信号与 Arp2/3 介导的肌动蛋白成核相匹配。最近的研究积累的证据揭示了 WRC 在神经元中的多种功能，表明其在决定各种跨突触信号模式的分子复合物组装方面起着关键作用。在这篇综述中，我们讨论了 WRC 在调节突触特性方面的生理作用的最新令人兴奋的发现，并强调了 WRC 功能障碍在各种脑疾病中的参与。