Small K W, Stefánsson E, Hatchell D L
Invest Ophthalmol Vis Sci. 1987 Apr;28(4):672-5.
We have found retinal blood flow to be decreased in diabetic dogs 5 months after the onset of diabetes, which is long before they can be expected to develop morphological changes of diabetic retinopathy. Retinal blood flow was determined using radionuclide labelled microspheres. In eight alloxan diabetic dogs without retinopathy, the retinal blood flow was 0.53 +/- 0.08 (mean +/- SE) ml/min/gm dry tissue weight. This compares with 0.91 +/- 0.17 (mean +/- SE) ml/min/gm dry tissue weight in seven normal dogs. The decreased blood flow in diabetic retinas is statistically significant (P = 0.05). Blood glucose levels did not significantly affect retinal blood flow. This data suggest that changes in retinal blood flow and oxidative metabolism may precede the morphological signs of diabetic retinopathy.
我们发现，糖尿病犬在糖尿病发病5个月后视网膜血流量就会减少，这远早于预期其出现糖尿病视网膜病变形态学改变的时间。视网膜血流量是使用放射性核素标记的微球来测定的。在8只无视网膜病变的四氧嘧啶糖尿病犬中，视网膜血流量为0.53±0.08（平均值±标准误）毫升/分钟/克干组织重量。与之相比，7只正常犬的视网膜血流量为0.91±0.17（平均值±标准误）毫升/分钟/克干组织重量。糖尿病视网膜中血流量的减少具有统计学意义（P = 0.05）。血糖水平对视网膜血流量没有显著影响。这些数据表明，视网膜血流量和氧化代谢的变化可能先于糖尿病视网膜病变的形态学体征出现。
