• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Hemoglobin La Desirade alpha A2 beta 2 129 (H7) Ala----Val: a new unstable hemoglobin.

作者信息

Merault G, Keclard L, Garin J, Poyart C, Blouquit Y, Arous N, Galacteros F, Feingold J, Rosa J

出版信息

Hemoglobin. 1986;10(6):593-605. doi: 10.3109/03630268609036564.

DOI:10.3109/03630268609036564
PMID:3557994
Abstract

Hemoglobin La Desirade is a new unstable hemoglobin variant arising from the substitution of beta 129 (H7) Ala for Val. Hb La Desirade exhibits a low oxygen affinity and normal heme-heme interaction. The variant was found in two unrelated black families in association with Hb S, Hb C or beta o thalassemia.

摘要

相似文献

1
Hemoglobin La Desirade alpha A2 beta 2 129 (H7) Ala----Val: a new unstable hemoglobin.
Hemoglobin. 1986;10(6):593-605. doi: 10.3109/03630268609036564.
2
Hemoglobin Beirut [alpha 2 beta 2(126)(H4)Val----Ala] in an Algerian family.一个阿尔及利亚家庭中的贝鲁特血红蛋白[α2β2(126)(H4)缬氨酸→丙氨酸]
Hemoglobin. 1986;10(6):651-4. doi: 10.3109/03630268609036568.
3
Low oxygen saturation and severe anemia in compound heterozygous Hb Louisville [β42(CD1)Phe→Leu] and Hb La Desirade [β129(H7)Ala→Val].
Hematology. 2017 Mar;22(2):114-118. doi: 10.1080/10245332.2016.1231989. Epub 2016 Sep 27.
4
Hemoglobin Sendagi (beta 42 Phe----Val): a new unstable hemoglobin variant having an amino acid substitution at CD1 of the beta-chain.
Hemoglobin. 1986;10(5):469-81. doi: 10.3109/03630268609014132.
5
Hemoglobin Crete (beta 129 ala leads to pro): a new high-affinity variant interacting with beta o -and delta beta o -thalassemia.血红蛋白克里特（β129丙氨酸突变为脯氨酸）：一种与β0和δβ0地中海贫血相互作用的新型高亲和力变体。
Blood. 1979 Jul;54(1):54-63.
6
Hemoglobin Dhonburi alpha 2 beta 2 126 (H4) Val----Gly: a new unstable beta variant producing a beta-thalassemia intermedia phenotype in association with beta zero-thalassemia.
Am J Hematol. 1990 Oct;35(2):96-9. doi: 10.1002/ajh.2830350206.
7
A new unstable and low oxygen affinity hemoglobin variant: Hb Stanmore [beta 111(G13)Val----Ala].
Hemoglobin. 1991;15(1-2):53-65. doi: 10.3109/03630269109072484.
8
Further characterization of Hb Henri Mondor or alpha 2 beta 2(26)(B8)Glu----Val.血红蛋白亨利·蒙多（Hb Henri Mondor）或α2β2(26)(B8)谷氨酸→缬氨酸的进一步特征分析。
Hemoglobin. 1987;11(1):1-11. doi: 10.3109/03630268709036574.
9
Hemoglobin Warsaw (Phe beta 42(CD1)----Val), an unstable variant with decreased oxygen affinity. Characterization of its synthesis, functional properties, and structure.华沙血红蛋白（β链第42位苯丙氨酸（CD1）→缬氨酸），一种氧亲和力降低的不稳定变体。对其合成、功能特性及结构的表征。
J Biol Chem. 1990 Jan 5;265(1):126-32.
10
Association of Hb S [beta 6(A3)Glu----Val] and Hb I-interlaken [alpha 15(A13)Gly----Asp] in a Sicilian man; review of the occurrence of Hb I-interlaken in Sicily.
Hemoglobin. 1989;13(4):403-10. doi: 10.3109/03630268909003403.

引用本文的文献

1
The beta thalassaemia trait in Jamaica.牙买加的β地中海贫血特质
J Community Genet. 2023 Aug;14(4):355-360. doi: 10.1007/s12687-023-00657-9. Epub 2023 Jun 30.
2
Clinical and Laboratory Features of Hemoglobin La Desirade Variant in Association with Sickle Cell and Alpha Thalassemia Genes.血红蛋白拉代西拉德变异体与镰状细胞和α地中海贫血基因相关的临床和实验室特征
Mediterr J Hematol Infect Dis. 2021 Jan 1;13(1):e2021010. doi: 10.4084/MJHID.2021.010. eCollection 2021.
3
Investigation of mutations in the HBB gene using the 1,000 genomes database.
利用千人基因组数据库对HBB基因中的突变进行研究。
PLoS One. 2017 Apr 5;12(4):e0174637. doi: 10.1371/journal.pone.0174637. eCollection 2017.
4
Sequence-based prioritization of nonsynonymous single-nucleotide polymorphisms for the study of disease mutations.基于序列的非同义单核苷酸多态性优先级排序用于疾病突变研究
Am J Hum Genet. 2007 Aug;81(2):346-60. doi: 10.1086/519747. Epub 2007 Jun 22.