[Results of an interdisciplinary study of primary inoperable stage T3 and T4 squamous cell carcinoma of the mouth, oropharynx and hypopharynx].

From Dec. 1980 to May 1984 26 patients with inoperable carcinomas of oral cavity, oropharynx and hypopharynx, were treated by us by a primary systemic chemotherapy. At all there were 95 patients with carcinoma of oral cavity, oropharynx, and hypopharynx, among these in 62 cases primary surgery was possible. In seven cases no tumor specific therapy was possible. A complete remission (CR) was obtained in 17% of tumors, partial remission (PR) in 39%. The results after subsequent operation (5 patient underwent operation) and radiation (all patients underwent radiation) were 35% CR and 26% PR. The median survival time of the patients with the multimodality-therapy was 13 months. Now 7 patients are alive with NED between 12+ and 38+ months.