头孢地嗪，一种氨噻唑基头孢菌素。V. 头孢地嗪系列的合成与构效关系。
Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series.
作者信息
Blumbach J, Dürckheimer W, Ehlers E, Fleischmann K, Klesel N, Limbert M, Mencke B, Reden J, Scheunemann K H, Schrinner E
出版信息
J Antibiot (Tokyo). 1987 Jan;40(1):29-42. doi: 10.7164/antibiotics.40.29.
PMID:3558116
Abstract
The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC in mice and dogs.
摘要
描述了头孢地嗪（HR 221，1a）及其类似物和衍生物的合成、体外抗菌活性和药代动力学行为。在本次比较中，头孢地嗪因其在小鼠和犬体内具有高抗菌活性、延长的消除半衰期和高药时曲线下面积之间的平衡而脱颖而出。
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