The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, China.
Luzhou People's Hospital, Luzhou, 646100, China.
Sci Rep. 2022 May 17;12(1):8153. doi: 10.1038/s41598-022-11692-w.
Volatile oil from traditional Chinese medicine has various biological activities and has pharmacological activities in the central nervous system, digestive system, cardiovascular system, respiratory system, etc. These oils are widely used in clinical practice. However, the development of their clinical applications is restricted due to the disadvantages of volatile oils, such as high stimulation, high volatility and poor stability. To improve the stability of a volatile oil in the preparation process, its volatilization and stable release must be controlled. In this paper, porous starch was used as a solid carrier material, and liquid volatile oil was solidified by physical adsorption. GC-MS was used to determine the chemical constituents of the volatile oil, solidified powder and tablets, and the volatilization rules of 34 chemical constituents were analysed statistically. The solidified volatile oil/porous starch powder was characterized by XRD, TGA and DSC, and the VOCs of the volatile oil before and after solidification were analysed by portable GC-MS. Finally, the stable release of the volatile oil could be optimized by changing the porous starch ratio in the formulation. Volatilization was shown to be closely related to the peak retention time and chemical composition, which was consistent with the theory of flavour. The physical properties and chemical composition of the volatile oil did not change after curing, indicating that the adsorption of the volatile oil by porous starch was physical adsorption. In this paper, the porous starch-solidified volatile oil had a slow-release effect, and the production process is simple, easy to operate, and has high application value.
中药挥发油具有多种生物活性，在中枢神经系统、消化系统、心血管系统、呼吸系统等方面具有药理活性。这些油在临床实践中得到了广泛应用。然而，由于挥发油的缺点，如刺激性高、挥发性高、稳定性差，其临床应用的发展受到限制。为了提高挥发油在制剂过程中的稳定性，必须控制其挥发和稳定释放。本文以多孔淀粉为固体载体材料，通过物理吸附将液态挥发油固化。采用 GC-MS 对挥发油、固化粉末和片剂的化学成分进行了测定，并对 34 种化学成分的挥发规律进行了统计分析。采用 XRD、TGA 和 DSC 对固化挥发油/多孔淀粉粉末进行了表征，并采用便携式 GC-MS 对固化前后挥发油中的 VOCs 进行了分析。最后，通过改变配方中多孔淀粉的比例来优化挥发油的稳定释放。挥发与峰保留时间和化学成分密切相关，这与风味理论一致。固化后，挥发油的物理性质和化学组成没有变化，表明多孔淀粉对挥发油的吸附是物理吸附。本文研究的多孔淀粉固化挥发油具有缓释效果，且生产工艺简单、易于操作，具有较高的应用价值。
