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改性琥珀颗粒作为稳定剂构建水包油型皮克林乳液以提高香精油的热稳定性

Modified Amber Particles as a Stabilizer to Construct Oil-in-Water Pickering Emulsions for Improved Thermal Stability of Essential Oil.

作者信息

Qu Zhonghuan, Shi Yajun, Zhang Xiaofei, Luan Fei, Guo Dongyan, Zhai Bingtao, Sun Jing, Zhang Dingkun, Zou Junbo, Zhu Maomao

机构信息

Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

出版信息

ACS Omega. 2024 May 4;9(19):20773-20790. doi: 10.1021/acsomega.3c08110. eCollection 2024 May 14.

DOI:10.1021/acsomega.3c08110
PMID:38764633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11097161/
Abstract

Lingzhu Pulvis is a classic formulation for treating febrile convulsions in children. However, essential oil (AT-EO) in this prescription is prone to volatilization and oxidation, compromising the efficacy and quality control of this formulation. Herein, based on the concept of "combination of medicine and adjuvant", Pickering emulsion technology was applied to enhance the stability of AT-EO using modified amber as a stabilizer. Amber was a resinous medicinal powder in Lingzhu Pulvis and was modified into a suitable stabilizer for Pickering emulsion through surface modification. A thermal stability study indicated that Pickering emulsion, stabilized by modified amber, exhibited a higher retention rate of AT-EO and lower levels of peroxide value and malondialdehyde content compared to those of the pure AT-EO group after heat treatment at 40 °C for 1, 3, and 8 h. Additionally, component analysis in content and composition revealed that the volatile components of AT-EO in the Pickering emulsion were more stable during the thermal treatment process. This study convincingly illustrates the potential of a Pickering emulsion stabilized with modified medicinal powders to improve the thermal stability of the essential oil.

摘要

羚珠散是治疗小儿高热惊厥的经典方剂。然而，该方剂中的挥发油（AT-EO）易挥发和氧化，影响了该制剂的疗效和质量控制。在此，基于“药辅合一”的理念，采用Pickering乳液技术，以改性琥珀为稳定剂提高AT-EO的稳定性。琥珀是羚珠散中的一种树脂类药粉，通过表面改性将其制成适合Pickering乳液的稳定剂。热稳定性研究表明，与纯AT-EO组相比，经改性琥珀稳定的Pickering乳液在40℃分别热处理1、3和8小时后，AT-EO的保留率更高，过氧化物值和丙二醛含量更低。此外，含量和成分分析表明，Pickering乳液中AT-EO的挥发性成分在热处理过程中更稳定。该研究令人信服地说明了用改性药粉稳定的Pickering乳液在提高挥发油热稳定性方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/32010f3a6643/ao3c08110_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/44a359d7b147/ao3c08110_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/2d873f769876/ao3c08110_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/cdef8c3cee02/ao3c08110_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/0667b730f048/ao3c08110_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/ce9857b2cec1/ao3c08110_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/5fb29c8755d5/ao3c08110_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/3dfec28bf545/ao3c08110_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/32010f3a6643/ao3c08110_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/44a359d7b147/ao3c08110_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/2d873f769876/ao3c08110_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/cdef8c3cee02/ao3c08110_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/0667b730f048/ao3c08110_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/ce9857b2cec1/ao3c08110_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/5fb29c8755d5/ao3c08110_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/3dfec28bf545/ao3c08110_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/11097161/32010f3a6643/ao3c08110_0008.jpg

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