Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, Brain Science and Technology Research Center and Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Life Science Building 1-209, 800 Dongchuan Road, Shanghai, 200240, China.
Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA.
Sci Rep. 2022 May 17;12(1):8170. doi: 10.1038/s41598-022-12066-y.
During their first year of medical residency (internship), 35% of training physicians in the United States suffer at least one depression episode. We assessed whether there is a similar increase of depression among first year residents in China, and identified predictors of depression in the two systems. 1006 residents across three cohorts (2016-2017, 2017-2018 and 2018-2019) at Shanghai Jiao Tong University and Peking Union Medical College were assessed in parallel with three cohorts of 7028 residents at 100 + US institutions. The Patient Health Questionnaire-9 (PHQ-9) depressive symptoms were measured at baseline and quarterly. Demographic, personal and residency factors were assessed as potential predictors of PHQ-9 depression scores. Similar to training interns in the US, the proportion of participants in China who met depression criteria at least once during the first year of residency increased substantially, from 9.1 to 35.1%. History of depression and symptoms at baseline were common factors significantly associated with depression during residency. By contrast, neuroticism, early family environment, female gender and not being coupled were associated with depression risk only in the US, while young age was a predictor of depression only in China. Fear of workplace violence also was a predictor in China. Long duty hours and reduced sleep duration emerged as training predictors of depression in both countries. The magnitude of depression increase and work-related drivers of depression were similar between China and the US, suggesting a need for effective system reforms in both systems.
在医学住院医师规范化培训的第一年,35%的美国培训医师至少经历过一次抑郁发作。我们评估了中国第一年住院医师是否存在类似的抑郁发生率增加,并确定了这两个体系中抑郁的预测因素。来自上海交通大学和北京协和医学院的三个队列(2016-2017、2017-2018 和 2018-2019)的 1006 名住院医师与来自 100 多家美国机构的三个队列(2016-2017、2017-2018 和 2018-2019)的 7028 名住院医师同时进行评估。在基线和每季度评估患者健康问卷-9(PHQ-9)抑郁症状。评估人口统计学、个人和住院医师因素,作为 PHQ-9 抑郁评分的潜在预测因素。与美国的培训住院医师类似,中国第一年住院医师中至少有一次符合抑郁标准的参与者比例从 9.1%大幅增加到 35.1%。抑郁病史和基线症状是与住院期间抑郁显著相关的共同因素。相比之下,神经质、早期家庭环境、女性性别和未婚是与美国抑郁风险相关的因素,而年龄较轻是中国抑郁的预测因素。对工作场所暴力的恐惧也是中国的一个预测因素。长时间工作和睡眠时间减少是两国培训中抑郁的预测因素。中国和美国的抑郁发生率增加幅度和与工作相关的抑郁驱动因素相似,这表明这两个体系都需要进行有效的系统改革。