Stenzel Martina H
Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, University of New South Wales, Sydney NSW 2052, Australia.
ACS Macro Lett. 2013 Jan 15;2(1):14-18. doi: 10.1021/mz3005814. Epub 2012 Dec 14.
Various pathways to bioconjugates based on thiol chemistry are discussed. Thiol-halogeno, thiol-parafluoro, thiol-ene, thiol-yne, thiol-vinylsulfone and thiol-vinyl sulfone, thiol-maleimide, thiol-bisulfone, and thiol-pyridyl disulfide are well-established synthetic routes discovered in recent years as tools to marry polymers with biomolecules such as carbohydrates, proteins, peptide, DNA, antibodies, or other building blocks from nature.
本文讨论了基于硫醇化学制备生物共轭物的各种途径。硫醇-卤代、硫醇-对氟、硫醇-烯、硫醇-炔、硫醇-乙烯砜和硫醇-乙烯基砜、硫醇-马来酰亚胺、硫醇-双砜以及硫醇-吡啶二硫化物是近年来发现的成熟合成路线，可作为将聚合物与生物分子（如碳水化合物、蛋白质、肽、DNA、抗体或其他天然结构单元）结合的工具。
