Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease; State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health. 145 Middle Shandong Road, Shanghai, China.
Int J Med Sci. 2022 Mar 28;19(4):659-668. doi: 10.7150/ijms.64133. eCollection 2022.
Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. Here we review GFRα biological functions and discussed the evidence indicating whether GFRα signaling complex present novel opportunities for oncogenic intervention and treatment resistance. Thus, our work systematically reviewed the emerging role of GFRα family members in cancers, and provided novel insights for further researches.
神经胶质细胞系衍生的神经营养因子家族受体 α (GFRα) 成员已被广泛连接到有助于细胞生长、分化、细胞迁移和组织成熟的机制中。在这里，我们回顾了 GFRα 的生物学功能，并讨论了表明 GFRα 信号复合物是否存在新的致癌干预和治疗抵抗机会的证据。因此，我们的工作系统地综述了 GFRα 家族成员在癌症中的新兴作用，并为进一步的研究提供了新的见解。
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