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对抑制基因突变频率下降特异性的直接证实。

A direct confirmation of the specificity of mutation frequency decline for suppressor mutations.

作者信息

Clarke C H

出版信息

Mol Gen Genet. 1978 Jul 4;162(3):345-6. doi: 10.1007/BF00268861.

DOI:10.1007/BF00268861
PMID:355838
Abstract

In a phage T7-resistand and galactose-sensitive derivative of E. coli B/r trp- it has been possible to show that MFD for UV-induced mutations is specific for Trp+ reversions (mainly of an ochre suppressor-containing type) but is without effect on galactose-resistant or D-fucose-resistant (ara Cc) forward mutations.

摘要

在大肠杆菌B/r trp-的一种对T7噬菌体有抗性且对半乳糖敏感的衍生物中，已能够表明紫外线诱导突变的MFD对Trp+回复突变（主要是含赭石型抑制基因的类型）具有特异性，但对耐半乳糖或耐D-岩藻糖（ara Cc）的正向突变没有影响。

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本文引用的文献

1
HOST-INDUCED MODIFICATION OF T-EVEN PHAGES DUE TO DEFECTIVE GLUCOSYLATION OF THEIR DNA.宿主诱导的T偶数噬菌体修饰，归因于其DNA糖基化缺陷
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2
Positive control of enzyme synthesis by gene C in the L-arabinose system.在L-阿拉伯糖系统中，基因C对酶合成的正调控。
J Bacteriol. 1965 Oct;90(4):946-57. doi: 10.1128/jb.90.4.946-957.1965.
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0 degree mutations in the galactose operon in E. coli. I. Genetic characterization.大肠杆菌中半乳糖操纵子的0度突变。I. 遗传学特征分析
Mol Gen Genet. 1967;100(2):178-89. doi: 10.1007/BF00333604.
4
Frameshift mutations in the lactose operon of E. coli.大肠杆菌乳糖操纵子中的移码突变。
Cold Spring Harb Symp Quant Biol. 1966;31:189-201. doi: 10.1101/sqb.1966.031.01.027.
5
Differential induction and repair of ultraviolet damage leading to true revesions and external suppressor mutations of an ochre codon in Escherichia coli B-r WP2.大肠杆菌B-r WP2中紫外线损伤的差异诱导与修复导致赭石密码子的真正回复和外抑制突变
Genetics. 1967 Dec;57(4):897-908. doi: 10.1093/genetics/57.4.897.
6
Do ultraviolet-induced mutations to streptomycin resistance exhibit susceptibility to mutation frequency decline?
Mutat Res. 1973 Aug;19(2):261-4. doi: 10.1016/0027-5107(73)90085-7.
7
Mutation frequency decline for streptomycin-resistant mutations induced by ultraviolet light in Escherichia coli B-r.大肠杆菌B-r中紫外线诱导的链霉素抗性突变的突变频率下降
Mutat Res. 1972 Feb;14(2):247-9. doi: 10.1016/0027-5107(72)90051-6.
8
Mutation frequency decline and the Clarke-Hill effect for UV-induced streptomycin-resistant mutations in an incision-defective E. coli strain.
Mutat Res. 1976 Dec;41(2-3):387-90. doi: 10.1016/0027-5107(76)90111-1.