Universidade Federal do Rio Grande do Norte, Departamento de Enfermagem, Natal, RN, Brasil.
Bolsista da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brasil.
Rev Lat Am Enfermagem. 2022;30:e3569. doi: 10.1590/1518-8345.5794.3569.
to analyze the factors associated with the failure of Hematopoietic Stem Cell Transplantation (HSCT) in patients undergoing Hematopoietic Stem Cell Retransplantation (HSCR).
this study implemented a quantitative approach and was a case-control type which addressed patients undergoing HSCR. To do so, a paired sample of two controls was used for each case (2:1). The case group consisted of the medical records of all patients who underwent HSCR (28) and the control group (56) of those who underwent only one transplant. Three variables guided the pairing: gender, diagnosis and type of transplant.
a total of 24 (85.71%) patients in the case group were re-transplanted due to disease relapse and four (14.29%) due to graft failure. There was a statistical difference in the analysis between patients who did not use ursodeoxycholic acid, opioid analgesics and immunosuppressants. The need for HSCR among those who used these medications inappropriately was 16.12, 12.79 and 4.5 times more likely, respectively, than those who used them correctly.
there was a difference regarding the reasons which led to the retransplantation and the analyzed subjects, and this study concluded that the predictive reason for retransplantation in the studied sample was disease relapse.
分析导致造血干细胞移植（HSCT）失败的相关因素，研究对象为接受造血干细胞再移植（HSCR）的患者。
本研究采用定量方法，属于病例对照类型，针对接受 HSCR 的患者。为此，每个病例使用两个对照（2:1）进行配对样本。病例组由所有接受 HSCR 的患者（28 例）的病历组成，对照组（56 例）由仅接受一次移植的患者组成。配对时考虑了三个变量：性别、诊断和移植类型。
在病例组中，共有 24 名（85.71%）患者因疾病复发而进行了再移植，4 名（14.29%）患者因移植物失败而进行了再移植。在未使用熊去氧胆酸、阿片类镇痛药和免疫抑制剂的患者中进行分析存在统计学差异。在使用这些药物不当时，需要进行 HSCR 的几率分别是正确使用时的 16.12 倍、12.79 倍和 4.5 倍。
导致再移植的原因和分析对象存在差异，本研究得出的结论是，在研究样本中，疾病复发是再移植的预测原因。
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