剪切波弹性成像在早期糖尿病肾病中的应用。
Shear wave elastography in early diabetic kidney disease.
机构信息
Tokat Gaziosmanpasa University, Faculty of Medicine, Department of Radiology - Tokat, Turkey.
Ankara University, Faculty of Engineering, Department of Biomedical Engineering - Ankara, Turkey.
出版信息
Rev Assoc Med Bras (1992). 2022 May 13;68(6):765-769. doi: 10.1590/1806-9282.20211042. eCollection 2022.
OBJECTIVE
This study aimed to analyze the kidneys among the subjects with early stages of type 2 diabetic kidney disease by shear wave elastography quantitatively.
METHODS
A total of 108 patients with type 2 diabetic kidney disease and 17 control subjects were enrolled. According to the estimated glomerular filtration rate and urinary albumin-to-urinary creatinine ratio, patients were classified into stages 1 to 3 diabetic kidney disease. Grayscale ultrasound andshear wave elastography were performed. The sizes, depths, and shear wave elastography values were recorded. These parameters were compared between the diabetic kidney disease and the control subjects.
RESULTS
The mean shear wave elastography values were significantly higher in the diabetic kidney disease group (10.156±1.75 kPa vs. 8.241±1.4 kPa; p<0.001). We obtained statistically significantly higher shear wave elastography values in stages 2 and 3 diabetic kidney disease subjects than control subjects and in patients with stage 3 diabetic kidney disease compared to those with stage 1 diabetic kidney disease (p<0.05 for all). We obtained a cutoff value of 9.23 kPa for predicting diabetic kidney disease in early stages, with a sensitivity of 67% and a specificity of 82%.
CONCLUSION
Shear wave elastography may be used as a noninvasive, simple, and quantitative method to provide diagnostic information as a part of routine management of patients with type 2 diabetes mellitus, especially in the early stages of diabetic kidney disease.
目的
本研究旨在通过剪切波弹性成像定量分析 2 型糖尿病早期肾病患者的肾脏。
方法
共纳入 108 例 2 型糖尿病肾病患者和 17 例对照者。根据估算的肾小球滤过率和尿白蛋白/尿肌酐比值，将患者分为 1 至 3 期糖尿病肾病。进行灰阶超声和剪切波弹性成像检查，记录大小、深度和剪切波弹性成像值。比较糖尿病肾病组与对照组之间的这些参数。
结果
糖尿病肾病组的平均剪切波弹性成像值显著升高（10.156±1.75 kPa 比 8.241±1.4 kPa；p<0.001）。我们发现 2 期和 3 期糖尿病肾病患者的剪切波弹性成像值明显高于对照组，且 3 期糖尿病肾病患者高于 1 期糖尿病肾病患者（均 p<0.05）。我们获得了 9.23 kPa 的预测早期糖尿病肾病的截断值，其敏感性为 67%，特异性为 82%。
结论
剪切波弹性成像可能作为一种非侵入性、简单和定量的方法，为 2 型糖尿病患者的常规管理提供诊断信息，尤其是在糖尿病肾病的早期阶段。
Zotero 插件