University of Health Sciences Turkey, Haydarpasa Numune Training and Research Hospital, Department of General Surgery - Istanbul, Turkey.
University of Health Sciences Turkey, Sisli Hamidiye Etfal Training and Research Hospital, Department of General Surgery - Istanbul, Turkey.
Rev Assoc Med Bras (1992). 2022 May;68(5):664-669. doi: 10.1590/1806-9282.20220037.
This study aimed to examine the prognostic effect of the tumor-stroma ratio, which has been shown to have prognostic value in various cancers, in patients with gallbladder cancer who have undergone curative resection.
The records of gallbladder cancer patients who underwent surgical treatment in our clinic between December 2005 and March 2021 were analyzed retrospectively. The hematoxylin and eosin-stained sections representing the tumors were evaluated under light microscopy to determine tumor-stroma ratio, and based on the results, <50% was defined as the stroma-rich and ≥50% as the stroma-poor groups.
A total of 28 patients, including 20 females and 8 males, with a mean age of 64.6 years, were included in this study. Stroma-poor and stroma-rich tumors were detected in 15 and 13 patients, respectively. There was no statistically significant relationship identified between tumor-stroma ratio and advanced age, gender, serum levels of carbohydrate antigen 19-9 and carcinoembryonic antigen, incidental or nonincidental diagnosis, jaundice, adjacent organ or structure resection, tumor location, grades 1-2 or 3, T1/T2 or T3/T4, N0 or N1/N2, M stage, American Joint Committee on Cancer stage, lymphovascular invasion, and perineural invasion. The stroma-poor and stroma-rich groups had a 5-year survival rate of 30% and 19.2% and a median overall survival of 25.7 and 15.1 months, respectively, with no statistically significant difference between the groups (p=0.526).
A low tumor-stroma ratio tended to be a poor prognostic factor in gallbladder cancer, although not to a statistically significant degree. This can be considered one of the preliminary studies, as further studies involving larger groups are needed.
本研究旨在探讨肿瘤间质比在胆囊癌患者根治性切除术后的预后价值。
回顾性分析 2005 年 12 月至 2021 年 3 月在我院接受手术治疗的胆囊癌患者的病历资料。在光学显微镜下评估代表肿瘤的苏木精和伊红染色切片，以确定肿瘤间质比，并根据结果将<50%定义为间质丰富组，≥50%定义为间质缺乏组。
共纳入 28 例患者，其中女性 20 例，男性 8 例，平均年龄 64.6 岁。15 例患者为间质缺乏组，13 例患者为间质丰富组。肿瘤间质比与年龄、性别、血清糖链抗原 19-9 和癌胚抗原水平、偶然或非偶然诊断、黄疸、邻近器官或结构切除、肿瘤位置、分级 1-2 或 3、T1/T2 或 T3/T4、N0 或 N1/N2、M 期、美国癌症联合委员会分期、淋巴血管侵犯和神经周围侵犯之间均无统计学显著关系。间质缺乏组和间质丰富组的 5 年生存率分别为 30%和 19.2%，中位总生存期分别为 25.7 个月和 15.1 个月，两组间无统计学差异（p=0.526）。
在胆囊癌中，低肿瘤间质比倾向于成为预后不良的因素，但未达到统计学显著程度。这可以被认为是初步研究之一，因为需要进一步进行涉及更大样本的研究。
