Göbel V, Jürgens H, Etspüler G, Kemperdick H, Jungblut R M, Stienen U, Göbel U
J Cancer Res Clin Oncol. 1987;113(2):187-91. doi: 10.1007/BF00391442.
A total of 60 consecutive patients with localized Ewing's sarcoma of bone who were entered into the Cooperative Ewing's Sarcoma Study of the German Society of Pediatric Oncology from January 1981 until April 1985 were evaluable for tumor volume at diagnosis. The tumor volume was calculated from plain X-rays and CT scans as ellipsoidal or cylindrical depending on the tumor configuration and presence or absence of a soft tissue component. The 3-year disease-free survival rate according to Kaplan-Meier life table analysis was 78% for tumors with a volume less than 100 ml compared to 17% for tumors greater than or equal to 100 ml volume. These results were independent of the site of the tumor, though larger tumors were primarily located in central and proximal extremity sites. Maximal tumor extension was less precise than tumor volume in predicting prognosis. The ratio of tumor volume to body surface area, body length, or body weight did not increase the ability to separate prognostic groups compared to tumor volume. The better prognosis for patients following radical surgery seems to be in part due to a biased distribution of tumor volumes within local therapy groups, since more patients with smaller tumors had surgery for local control.
1981年1月至1985年4月期间，共有60例连续性骨局限性尤因肉瘤患者进入德国小儿肿瘤学会尤因肉瘤合作研究，这些患者在诊断时可评估肿瘤体积。根据肿瘤形态以及是否存在软组织成分，通过X线平片和CT扫描将肿瘤体积计算为椭圆形或圆柱形。根据Kaplan-Meier生存表分析，体积小于100 ml的肿瘤3年无病生存率为78%，而体积大于或等于100 ml的肿瘤为17%。这些结果与肿瘤部位无关，尽管较大的肿瘤主要位于中央和近端肢体部位。在预测预后方面，肿瘤最大径线不如肿瘤体积精确。与肿瘤体积相比，肿瘤体积与体表面积、体长或体重的比值并未增加区分预后组别的能力。接受根治性手术患者预后较好，部分原因可能是局部治疗组内肿瘤体积分布存在偏差，因为更多肿瘤较小的患者接受了手术以进行局部控制。
