工作记忆和奖励提高了内侧前额叶皮层中动物位置编码的准确性。
Working memory and reward increase the accuracy of animal location encoding in the medial prefrontal cortex.
机构信息
Section on Synapse Development Plasticity, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, United States.
Machine Learning Team, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, United States.
出版信息
Cereb Cortex. 2023 Feb 20;33(5):2245-2259. doi: 10.1093/cercor/bhac205.
The ability to perceive spatial environments and locate oneself during navigation is crucial for the survival of animals. Mounting evidence suggests a role of the medial prefrontal cortex (mPFC) in spatially related behaviors. However, the properties of mPFC spatial encoding and how it is influenced by animal behavior are poorly defined. Here, we train the mice to perform 3 tasks differing in working memory and reward-seeking: a delayed non-match to place (DNMTP) task, a passive alternation (PA) task, and a free-running task. Single-unit recording in the mPFC shows that although individual mPFC neurons exhibit spatially selective firing, they do not reliably represent the animal location. The population activity of mPFC neurons predicts the animal location. Notably, the population coding of animal locations by the mPFC is modulated by animal behavior in that the coding accuracy is higher in tasks involved in working memory and reward-seeking. This study reveals an approach whereby the mPFC encodes spatial positions and the behavioral variables affecting it.
在导航过程中感知空间环境和定位自身的能力对动物的生存至关重要。越来越多的证据表明，内侧前额叶皮层（mPFC）在与空间相关的行为中起作用。然而，mPFC 的空间编码特性以及它如何受到动物行为的影响还没有被很好地定义。在这里，我们训练老鼠执行 3 项任务，这些任务在工作记忆和寻求奖励方面有所不同：延迟非匹配到位置（DNMTP）任务、被动交替（PA）任务和自由运行任务。mPFC 中的单细胞记录表明，尽管单个 mPFC 神经元表现出空间选择性放电，但它们并不可靠地代表动物位置。mPFC 神经元的群体活动可以预测动物的位置。值得注意的是，mPFC 对动物位置的群体编码受到动物行为的调节，即在涉及工作记忆和寻求奖励的任务中，编码准确性更高。这项研究揭示了一种方法，即 mPFC 对空间位置进行编码，并对影响它的行为变量进行编码。
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