University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Sci Rep. 2022 May 18;12(1):8317. doi: 10.1038/s41598-022-12478-w.
The aim of this study was to detect a response difference in primary (PLC) and secondary liver tumors (SLC) with magnetic resonance elastography (MRE) after TACE therapy. Thirty-one patients (25/31 male; mean age 69.6 years [range: 39-85 years]) with repeated TACE therapy of HCC were compared with twenty-seven patients (27/27 female; mean age 61.2 years [range 39-81 years]) with repeated TACE therapy of metastatic liver disease due to breast cancer. Both groups underwent either one (n = 31) or two (n = 27) repetitive magnetic resonance imaging (MRI) and MRE exams in 4- to 6-week intervals using a 1.5-T-scanner. MRE-based liver stiffness and size measurements were evaluated in tumorous lesions and in healthy liver lobe controls. PLC showed a significantly larger tumor size compared to SLC (26.4 cm vs. 11 cm, p = 0.007) and a higher degree of stiffness (5.8 kPa vs. 5.1 kPa, p = 0.04). Both tumors decreased in size during the cycles (PLC: p = 0.8 and SLC: p < 0.0001) and lesions showed an increase in stiffness (PLC: p = 0.002 and SLC: p = 0.006). MRE demonstrates that PLC and SLC have similar responses to TACE therapy. PLC had a greater increase in stiffness and SLC got smaller. An increasing stiffness and decrease in size could show a good response.
本研究旨在通过磁共振弹性成像（MRE）检测经 TACE 治疗后原发性（PLC）和继发性肝肿瘤（SLC）的反应差异。31 例（25/31 例男性；平均年龄 69.6 岁[范围：39-85 岁]）接受重复 HCC 的 TACE 治疗，与 27 例（27/27 例女性；平均年龄 61.2 岁[范围 39-81 岁]）接受重复转移性乳腺癌肝疾病的 TACE 治疗进行比较。两组均在 4-6 周的间隔内使用 1.5-T 扫描仪进行一次（n=31）或两次（n=27）重复磁共振成像（MRI）和 MRE 检查。在肿瘤病变和健康肝叶对照中评估基于 MRE 的肝硬度和大小测量值。PLC 与 SLC 相比，肿瘤大小明显更大（26.4cm 比 11cm，p=0.007），硬度更高（5.8kPa 比 5.1kPa，p=0.04）。在周期内，两种肿瘤的大小均减小（PLC：p=0.8 和 SLC：p<0.0001），病变的硬度增加（PLC：p=0.002 和 SLC：p=0.006）。MRE 表明 PLC 和 SLC 对 TACE 治疗有相似的反应。PLC 的硬度增加更大，SLC 的体积减小。硬度增加和体积减小可能表明反应良好。
