Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, 230032, Hefei, Anhui, China.
Mol Biol Rep. 2022 Aug;49(8):8145-8152. doi: 10.1007/s11033-022-07565-0. Epub 2022 May 18.
Krüppel-like factors (KLFs) are a family of transcription factors characterised by zinc-finger structures at the C-terminal. They play the key roles in cell proliferation, differentiation, and migration, as well as in embryonic development. They have been widely expressed in multiple systems in vivo, and their dysregulation is closely associated with a variety of human diseases. Glycolipid metabolism is a complex physiological process which can be regulated at the transcriptional level. Glycolipid metabolic diseases, such as obesity, non-alcoholic fatty liver disease, diabetes, and their complications, are a serious threat to human health. Recently, increasing studies have shown that KLFs are closely related to glycolipid metabolism and energy balance of the liver, adipose tissue, heart, skeletal muscle, lung, pancreas, and nervous system. In this review, we focused on the correlation between the subtypes of the KLF family and glycolipid metabolic diseases to describe new directions and trends in endocrine and glycolipid metabolic disease treatments.
Krüppel 样因子（KLFs）是一类转录因子，其特征在于 C 末端的锌指结构。它们在细胞增殖、分化和迁移以及胚胎发育中发挥关键作用。它们在体内的多个系统中广泛表达，其失调与多种人类疾病密切相关。糖脂代谢是一个复杂的生理过程，可以在转录水平上进行调节。糖脂代谢疾病，如肥胖、非酒精性脂肪肝疾病、糖尿病及其并发症，严重威胁着人类健康。最近，越来越多的研究表明 KLFs 与肝脏、脂肪组织、心脏、骨骼肌、肺、胰腺和神经系统的糖脂代谢和能量平衡密切相关。在这篇综述中，我们重点介绍了 KLF 家族亚型与糖脂代谢疾病之间的相关性，以描述内分泌和糖脂代谢疾病治疗的新方向和趋势。
