Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, 1-8 Yamada-oka, Suita 565-0871, Osaka, Japan.
Division of Special Care Dentistry, Osaka University Dental Hospital, 1-8 Yamada-oka, Suita 565-0871, Osaka, Japan.
Int J Mol Sci. 2022 Dec 2;23(23):15174. doi: 10.3390/ijms232315174.
Kruppel-like factors (KLFs) belong to a large group of zinc finger-containing transcription factors with amino acid sequences resembling the Drosophila gap gene . Since the first report of molecular cloning of the family gene, the number of KLFs has increased rapidly. Currently, 17 murine and human KLFs are known to play crucial roles in the regulation of transcription, cell proliferation, cellular differentiation, stem cell maintenance, and tissue and organ pathogenesis. Recent evidence has shown that many KLF family molecules affect skeletal cells and regulate their differentiation and function. This review summarizes the current understanding of the unique roles of each KLF in skeletal cells during normal development and skeletal pathologies.
Kruppel 样因子（KLFs）属于一大类含锌指转录因子，其氨基酸序列类似于果蝇的缺口基因。自首次报道克隆家族基因以来，KLFs 的数量迅速增加。目前已知 17 种鼠类和人类 KLFs 在转录调控、细胞增殖、细胞分化、干细胞维持以及组织和器官发病机制中发挥着关键作用。最近的证据表明，许多 KLF 家族分子影响骨骼细胞并调节其分化和功能。本综述总结了目前对 KLF 在骨骼细胞正常发育和骨骼病理过程中的独特作用的认识。
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