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采用邻苯二甲醛衍生化高效液相色谱法和荧光检测法测定血浆中L-丁硫氨酸-（S，R）-亚砜亚胺

Determination of L-buthionine-(S,R)-sulfoximine in plasma by high-performance liquid chromatography with o-phthalaldehyde derivatization and fluorometric detection.

作者信息

Duff R, Murrill E

出版信息

J Chromatogr. 1987 Jan 9;385:275-82. doi: 10.1016/s0021-9673(01)94640-0.

DOI:10.1016/s0021-9673(01)94640-0
PMID:3558582
Abstract

The development of a high-performance liquid chromatography system for the analysis of L-buthionine-(S,R)-sulfoximine (BSO) in human plasma is described. o-Phthalaldehyde derivatization and fluorescence detection were used. The R- and S-BSO peaks were partially separated from each other and completely separated from the matrix components. The limit of detection for BSO was 2 micrograms/ml plasma.

摘要

描述了一种用于分析人血浆中L-丁硫氨酸-(S,R)-亚砜亚胺（BSO）的高效液相色谱系统的开发。采用邻苯二甲醛衍生化和荧光检测。R-BSO和S-BSO峰彼此部分分离，并与基质成分完全分离。BSO的检测限为2微克/毫升血浆。

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