Bogdanov A A
Mol Biol (Mosk). 1978 Jul-Aug;12(4):725-36.
The paper summarizes recent data on the secondary and tertiary structure of RNA in ribosomes. The participation of RNA in intraribosomal interactions and the role of these interactions in organization of ribosomal subunits are discussed. The following conclusions are made: 1) the structure of ribosomal subunits is predominantly created with their RNA components; 2) RNA molecules in ribosomal subunits have a very compact structure; the formation of this structure is followed by the rearrangement of the secondary structure of RNA; 3) the small group of ribosomal proteins plays an important role in the folding of RNA in the compact conformation: they not only stabilize intraribosomal RNA conformation but probably induce new RNA-RNA contacts.
本文总结了核糖体中RNA二级和三级结构的最新数据。讨论了RNA在核糖体内部相互作用中的参与情况以及这些相互作用在核糖体亚基组织中的作用。得出以下结论：1）核糖体亚基的结构主要由其RNA组分形成；2）核糖体亚基中的RNA分子具有非常紧密的结构；这种结构的形成伴随着RNA二级结构的重排；3）一小部分核糖体蛋白在RNA折叠成紧密构象中起重要作用：它们不仅稳定核糖体内部RNA构象，而且可能诱导新的RNA-RNA接触。
