Deng Ling, Qiu Zhi-Xin, Wang Mao-Yun
Department of Respiratory and Critical Care Medicine, The First People's Hospital of Chongqing Liang Jiang New Area, Chongqing, China.
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
Ther Adv Psychopharmacol. 2022 May 14;12:20451253221094960. doi: 10.1177/20451253221094960. eCollection 2022.
Neuroleptic malignant syndrome (NMS) is a rare illness that results from reactions to antipsychotics. However, the diagnosis of NMS is challenging due to its atypical clinical presentation and unclear pathogenesis. We report the case of a patient with NMS induced by irregular use of antipsychotics, especially risperidone (RSP). He had typical hyperthermia, muscle rigidity and rhabdomyolysis, which led to renal impairment. We carefully analysed the mechanism by which NMS occurred in this patient. An interesting aspect of the case is the synergistic involvement of risperidone, antidepressants, opioids and stress. Because of these complex predisposing factors, it is difficult to completely rule out the diagnosis of malignant hyperthermia (MH). In addition, the rare phenomenon of elevated lipase and amylase was observed in this patient.
神经阻滞剂恶性综合征（NMS）是一种由抗精神病药物反应引起的罕见疾病。然而，由于其非典型的临床表现和不明的发病机制，NMS的诊断具有挑战性。我们报告了一例因不规则使用抗精神病药物，尤其是利培酮（RSP）诱发NMS的患者病例。他出现了典型的高热、肌肉强直和横纹肌溶解，进而导致肾功能损害。我们仔细分析了该患者发生NMS的机制。该病例一个有趣的方面是利培酮、抗抑郁药、阿片类药物和应激的协同作用。由于这些复杂的诱发因素，很难完全排除恶性高热（MH）的诊断。此外，该患者还出现了罕见的脂肪酶和淀粉酶升高现象。
