Papagrigorakis Eftychios, Vavourakis Michail, Vlachos Christos, Zachariou Dimitrios, Galanis Athanasios, Marougklianis Vasileios, Polyzois Vasileios, Pneumaticos Spiros
3rd Orthopaedic Department, KAT General Hospital of Attica, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
4th Orthopaedic Department, KAT General Hospital of Attica, Athens, GRC.
Cureus. 2022 Apr 14;14(4):e24151. doi: 10.7759/cureus.24151. eCollection 2022 Apr.
spp. are non-fermenting aerobic gram-negative rods found in humid environments, whose role as opportunistic human pathogens has lately been recognized. is one of the three members of the genus (together with and ). Bone infections by spp. are very rare. We report a case of femoral osteomyelitis caused by . Among literature search, only eight cases of bone infection due to the genus have been described, in all of which the causative agent was identified as . To our knowledge, this is the first reported case of osteomyelitis attributed to . Despite its low virulence, has specific characteristics that promote its spread and shows high antibiotic resistance, partly due to its ability to create a biofilm. Identification of spp. poses unique difficulties as the distinction between the species of the genus is not straightforward. Additionally, the bacteria may be misidentified as other closely related species. Recent data suggests that modern spectrometry and gene sequencing techniques are essential to avoid these pitfalls. Susceptibility data about the genus is limited and based on a small number of case reports, therefore there is no standardized antibiotic susceptibility testing and European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints exist. The report aims is to provide useful information on the antibiotic selection and treatment suggestions to be followed for bone infections caused by the genus, along with a review on the literature of this emerging opportunistic pathogen.
某某菌属是在潮湿环境中发现的非发酵需氧革兰氏阴性杆菌，其作为人类机会致病菌的作用最近已得到认可。某某菌属是某某属的三个成员之一（与某某菌和某某菌一起）。由某某菌属引起的骨感染非常罕见。我们报告一例由某某菌引起的股骨骨髓炎病例。在文献检索中，仅描述了8例由某某属引起的骨感染病例，所有病例中病原体均被鉴定为某某菌。据我们所知，这是首例报告的由某某菌引起的骨髓炎病例。尽管其毒力较低，但某某菌具有促进其传播的特定特征，并表现出高耐药性，部分原因是其能够形成生物膜。鉴定某某菌属存在独特困难，因为该属菌种之间的区分并不简单。此外，该细菌可能被误鉴定为其他密切相关的菌种。最新数据表明，现代光谱分析和基因测序技术对于避免这些陷阱至关重要。关于该属的药敏数据有限且基于少数病例报告，因此不存在标准化的抗生素药敏试验，也没有欧洲抗菌药物敏感性试验委员会（EUCAST）的断点。本报告旨在提供有关由某某属引起的骨感染的抗生素选择和治疗建议的有用信息，同时对这种新兴机会致病菌的文献进行综述。
