Raza Muhammad Ali, Jain Ashish, Mumtaz Maha, Mehmood Talha
Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, USA.
Cureus. 2022 Apr 15;14(4):e24164. doi: 10.7759/cureus.24164. eCollection 2022 Apr.
Amiodarone is a class III antiarrhythmic drug with a structure comparable to thyroid hormone and 37% iodine content by weight. In addition to direct drug cytotoxicity on thyroid cells, amiodarone deiodination in the body releases an excessive amount of iodine, which can impair thyroid function and cause hypothyroidism or thyrotoxicosis, including thyroid storm in susceptible individuals. In this report, we discuss the case of a 52-year-old woman who experienced a thyroid storm after being treated with amiodarone, eventually leading to her death.
胺碘酮是一种III类抗心律失常药物，其结构与甲状腺激素相似，碘含量按重量计为37%。除了对甲状腺细胞有直接的药物细胞毒性外，胺碘酮在体内脱碘会释放出过量的碘，这会损害甲状腺功能，导致甲状腺功能减退或甲状腺毒症，包括在易感个体中引发甲状腺风暴。在本报告中，我们讨论了一名52岁女性在接受胺碘酮治疗后发生甲状腺风暴，最终导致死亡的病例。
