Division of Pediatric Endocrinology, Children's Hospital of Orange County, Orange, CA, United States.
Department of Pediatrics, Division of Pediatric Gastroenterology and Endocrinology, University of Rochester Medical Center, Rochester, NY, United States.
Front Endocrinol (Lausanne). 2022 May 2;13:840361. doi: 10.3389/fendo.2022.840361. eCollection 2022.
The known markers of insulin resistance in obese children are well studied. However, they require serial measurements and complicated calculations. The objective is to study IGFBP-1 and its relation with other known risk measures.
The study included 98 New York City school students of diverse ethnic/racial backgrounds (57 males and 41 females), 11-15 years of age. Subjects were enrolled in a cross-sectional study, and anthropometric measures were collected. They underwent fasting intravenous glucose tolerance tests (IVGTT), and glucose, insulin, lipids, IGFBP-1, adiponectin and inflammatory markers were collected.
The subjects were stratified into 3 groups based upon the BMI Z-score. Out of all the subjects, 65.3% were in the group with a BMI Z-score <1 SDS, 16.3% subjects were in the group with a BMI Z-score of 1 to 2 SDS, and 18.4% of the subjects were in the group with a BMI Z-score of more than 2 SDS. The group with a BMI Z-score of more than 2 SDS had increased waist circumference (WC), body fat, increased fasting insulin, and triglycerides (TG). This group had decreased levels of adiponectin and HDL and low IGFBP-1 as compared to the group with BMI <1 SDS. The group with a BMI Z-score of 1 to 2 SDS had a decreased level of IGFBP-1 as compared to the group with a BMI Z-score less than 1 SDS. IGFBP-1 inversely correlated with age, WC, BMI, body fat, TG, and insulin levels. IGFBP-1 positively correlated with adiponectin and HDL levels.
IGFBP-1 in children can identify the presence of insulin resistance in the group with BMI 1 to 2 SDS, even before the known markers of insulin resistance such as elevated triglycerides and even before decreased HDL and adiponectin levels are identified.
肥胖儿童的胰岛素抵抗标志物已得到充分研究。然而，这些标志物需要进行连续测量和复杂的计算。本研究旨在探讨 IGFBP-1 及其与其他已知风险指标的关系。
本研究纳入了来自纽约市不同族裔/种族背景的 98 名 11-15 岁学生（男 57 名，女 41 名）。这些学生参与了一项横断面研究，采集了他们的人体测量学指标。并对他们进行了空腹静脉葡萄糖耐量试验（IVGTT），检测了血糖、胰岛素、血脂、IGFBP-1、脂联素和炎症标志物。
根据 BMI Z 评分，将所有受试者分为 3 组。在所有受试者中，65.3%的 BMI Z 评分<1 SDS，16.3%的 BMI Z 评分在 1 至 2 SDS 之间，18.4%的 BMI Z 评分>2 SDS。与 BMI <1 SDS 组相比，BMI Z 评分>2 SDS 组的腰围（WC）、体脂、空腹胰岛素和甘油三酯（TG）水平更高。该组的脂联素和高密度脂蛋白（HDL）水平较低，IGFBP-1 水平也较低。与 BMI <1 SDS 组相比，BMI Z 评分在 1 至 2 SDS 之间的组 IGFBP-1 水平也较低。IGFBP-1 与年龄、WC、BMI、体脂、TG 和胰岛素水平呈负相关，与脂联素和 HDL 水平呈正相关。
儿童 IGFBP-1 可在 BMI 为 1 至 2 SDS 的人群中识别出胰岛素抵抗的存在，甚至在已知的胰岛素抵抗标志物（如升高的 TG）出现之前，甚至在 HDL 和脂联素水平降低之前。
