Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Front Endocrinol (Lausanne). 2022 May 2;13:894935. doi: 10.3389/fendo.2022.894935. eCollection 2022.
Increasing evidence suggests a link between vitamin D and polycystic ovary syndrome (PCOS). However, whether vitamin D is related to hyperandrogenemia in PCOS is still inconclusive. The aim of our study is to elucidate the relationship between vitamin D and hyperandrogenemia in women with PCOS in China.
This is a cross-sectional study including 625 Chinese women with PCOS and 217 controls from January 2016 to June 2020. The anthropometric and biochemical parameters related to 25(OH)D, sex steroids, glucose and lipid profiles were measured.
Serum 25(OH)D levels were lower in women with PCOS than controls (33.99 ± 15.05 vs 36.58 ± 16.49 nmol/L, P = 0.034), especially lower in hyperandrogenic women with PCOS (32.79 ± 14.24 vs 36.21 ± 16.27 nmol/L, P = 0.007). Higher 25(OH)D levels were independently associated with lower risks of hyperandrogenemia after adjusting demographic, metabolic and hormonal confounders (OR = 0.982, 95% CI: 0.969 - 0.995, P = 0.006). Consistent results were observed in subgroup analyses. Among PCOS women with vitamin D deficiency, females with age ≥ 26 years had lower risks of hyperandrogenemia (OR = 0.611, 95% CI = 0.389 - 0.958, P = 0.032), while overweight patients had higher risks of hyperandrogenemia (OR = 2.202, 95% CI = 1.130 - 4.293, P = 0.020) after adjusting multiple confounders.
Our study reported lower vitamin D levels in Chinese women with PCOS, especially in those with hyperandrogenemia. An independent negative correlation between 25(OH)D and hyperandrogenemia was noted in PCOS. For PCOS women with vitamin D deficiency, females that have higher BMI with age < 26 years may be prioritized for hyperandrogenemia assessment.
越来越多的证据表明维生素 D 与多囊卵巢综合征（PCOS）之间存在关联。然而，维生素 D 是否与 PCOS 中的高雄激素血症有关仍不确定。我们的研究旨在阐明中国 PCOS 妇女中维生素 D 与高雄激素血症之间的关系。
这是一项横断面研究，纳入了 2016 年 1 月至 2020 年 6 月期间的 625 名中国 PCOS 妇女和 217 名对照者。测量了与 25（OH）D、性激素、葡萄糖和脂质谱相关的人体测量和生化参数。
PCOS 妇女的血清 25（OH）D 水平低于对照组（33.99 ± 15.05 比 36.58 ± 16.49 nmol/L，P = 0.034），尤其是高雄激素血症的 PCOS 妇女（32.79 ± 14.24 比 36.21 ± 16.27 nmol/L，P = 0.007）。在校正人口统计学、代谢和激素混杂因素后，较高的 25（OH）D 水平与较低的高雄激素血症风险独立相关（OR = 0.982，95%CI：0.969-0.995，P = 0.006）。亚组分析也得到了一致的结果。在维生素 D 缺乏的 PCOS 妇女中，年龄≥26 岁的女性高雄激素血症的风险较低（OR = 0.611，95%CI = 0.389-0.958，P = 0.032），而超重患者高雄激素血症的风险较高（OR = 2.202，95%CI = 1.130-4.293，P = 0.020），在调整了多个混杂因素后。
我们的研究报告了中国 PCOS 妇女维生素 D 水平较低，尤其是高雄激素血症的妇女。在 PCOS 中，25（OH）D 与高雄激素血症之间存在独立的负相关关系。对于维生素 D 缺乏的 PCOS 妇女，年龄<26 岁、BMI 较高的女性可能需要优先评估高雄激素血症。
