Czejka M J, Koch H P
J Chromatogr. 1987 Jan 23;413:181-7. doi: 10.1016/0378-4347(87)80225-6.
A rapid and sensitive isocratic high-performance liquid chromatography assay for the simultaneous and quantitative determination of thalidomide (alpha-phthalimidoglutarimide) and its major metabolites from human serum has been developed. The parent compound and the metabolites can be efficiently separated by reversed-phase chromatography using tetramethylammonium bromide as an ion-pair-forming reagent.
已开发出一种快速灵敏的等度高效液相色谱分析法，用于同时定量测定人血清中的沙利度胺（α-邻苯二甲酰亚胺基戊二酰亚胺）及其主要代谢物。使用溴化四甲基铵作为离子对形成试剂，通过反相色谱法可有效分离母体化合物及其代谢物。
