Piperidou Alexia, Drandakis Ioannis, Lefaki Maria-Aikaterini, Lakiotaki Eleftheria, Plyta Helen, Sypsa Georgia, Tsolakou-Dalekou Maria, Androulaki Maria, Panitsas Fotios, Plata Eleni, Korkolopoulou Penelope, Vassilakopoulos Theodoros P
Department of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, Greece.
First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece.
Gynecol Oncol Rep. 2022 Apr 30;41:100988. doi: 10.1016/j.gore.2022.100988. eCollection 2022 Jun.
Primary mediastinal large B- cell lymphoma (PMLBCL) is a mature aggressive B-cell lymphoma which affects mainly young and middle-aged women. The majority of patients present with bulky mediastinal lymphadenopathy. Extranodal involvement is a rare phenomenon at disease presentation. Herein, we describe a case of a young female with PMLBCL presenting with symptomatic, bulky ovarian involvement. The 23-year old patient presented at the Emergency Department with abdominal pain. The chest X-ray film revealed a mediastinal mass and CT scan revealed a large pelvic mass, possibly involving the ovaries. Due to the development of signs of acute abdomen, she was urgently transferred to the operation room where surgical resection of the right ovary and the adjacent mass was performed. The histological examination of the resected material revealed proliferation of PMLBCL cells. This is the first report in the scientific literature describing symptomatic ovarian mass as the initial mode of presentation of PMLBCL.
原发性纵隔大B细胞淋巴瘤（PMLBCL）是一种成熟的侵袭性B细胞淋巴瘤，主要影响年轻和中年女性。大多数患者表现为纵隔淋巴结肿大。在疾病初发时，结外受累是一种罕见现象。在此，我们描述一例年轻女性PMLBCL患者，以有症状的、巨大的卵巢受累为表现。这位23岁的患者因腹痛就诊于急诊科。胸部X线片显示纵隔肿块，CT扫描显示盆腔有一个大肿块，可能累及卵巢。由于出现急腹症体征，她被紧急转入手术室，行右卵巢及相邻肿块的手术切除。切除组织的组织学检查显示PMLBCL细胞增殖。这是科学文献中首次报道将有症状的卵巢肿块作为PMLBCL的初始表现方式。
