易于获得的手性烯基重氮硼烷的立体控制周环反应和自由基环加成反应
Stereocontrolled Pericyclic and Radical Cycloaddition Reactions of Readily Accessible Chiral Alkenyl Diazaborolidines.
作者信息
Zhang Mingkai, Xu Peilin, Vendola Alex J, Allais Christophe, Dechert Schmitt Anne-Marie, Singer Robert A, Morken James P
机构信息
Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.
Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06430, USA.
出版信息
Angew Chem Int Ed Engl. 2022 Jul 25;61(30):e202205454. doi: 10.1002/anie.202205454. Epub 2022 Jun 8.
Abstract
In this paper is described an easily synthesized chiral diazaborolidine that is inexpensive, stable, and provides excellent stereoselection across a number of reaction classes. These versatile compounds possess utility in four different classes of cycloaddition reactions, offering good yield and stereoselectivity. X-ray structure analysis provides insight about the origin of stereocontrol.
摘要
本文描述了一种易于合成的手性重氮硼烷，它价格低廉、稳定性好，并且在许多反应类型中都能提供出色的立体选择性。这些多功能化合物在四类不同的环加成反应中具有实用性，能提供良好的产率和立体选择性。X射线结构分析揭示了立体控制的起源。
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