Department of Clinical Microbiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
University of Copenhagen, Faculty of Health and Medical Sciences, Section of General Practice, Copenhagen, Denmark.
Infect Dis (Lond). 2022 Sep;54(9):651-655. doi: 10.1080/23744235.2022.2076903. Epub 2022 May 19.
The objective of this study was to compare antibiotic prescription rates in Denmark among elderly living in long-term care facilities to elderly living at home, with regards to total antibiotic use and antibiotic use for urinary tract infection.
This is an observational registry-based study. The study population included all elderly Danish residents aged ≥75 years in 2016. Linear regression models were used to examine the difference in antibiotic prescription rates between elderly living in long-term care facilities and elderly living at home. Results were adjusted for age, sex and comorbidity, the latter assessed the Charlson Comorbidity Index.
The study population consisted of 416,627 elderly. Regression models showed that elderly living in long-term care facilities were prescribed 1.7 [CI 1.7-1.7] prescriptions/individual/year more than elderly living at home. For urinary tract infections the difference between elderly living in long-term care facilities and elderly living at home was 1.2 [CI 1.2-1.3] prescriptions/individual/year.
Elderly living in long-term care facilities have a higher antibiotic prescribing rate than elderly living at home, despite controlling for age, sex and comorbidity. This indicates that long-term care facilities continuously should be a focus for antibiotic stewardship interventions.
本研究旨在比较丹麦长期护理机构中老年人与居家老年人的抗生素处方率，涉及总抗生素使用量和尿路感染抗生素使用量。
这是一项观察性基于登记的研究。研究人群包括 2016 年所有年龄≥75 岁的丹麦居民。线性回归模型用于检验长期护理机构中老年人与居家老年人之间抗生素处方率的差异。结果调整了年龄、性别和合并症，后者采用 Charlson 合并症指数评估。
研究人群包括 416627 名老年人。回归模型显示，长期护理机构中老年人的抗生素处方量比居家老年人多 1.7[CI 1.7-1.7]张/人/年。对于尿路感染，长期护理机构中老年人与居家老年人之间的差异为 1.2[CI 1.2-1.3]张/人/年。
尽管控制了年龄、性别和合并症，长期护理机构中老年人的抗生素处方率仍高于居家老年人。这表明长期护理机构应持续成为抗生素管理干预的重点。
