Chorioretinitis in a Post-chemotherapy Immunocompromised 9-Year-Old Child.

PURPOSE

To describe the management of bilateral chorioretinitis with in a post-chemotherapy immunocompromised young patient.

METHOD

A retrospective case report.

RESULT

A 9-year-old boy treated with chemotherapy for type 2 acute myeloid leukaemia was diagnosed with (formerly called ) fungaemia. Systematic ocular examination revealed chorioretinitis of the left eye becoming bilateral within the next 3 days. Therapy was based on systemic administration of voriconazole, amphotericin B and flucytosine associated with granulocytic stimulation without stabilizing the ophthalmological situation. Bilateral intravitreal injections of amphotericin B were administered. Voriconazole residual blood concentration was monitored to adjust daily dose. Final best corrected visual acuity in the right eye was 20/50 and 20/20 in the left eye.

CONCLUSION

This is the first report of chorioretinitis with . Because of its unpredictable pharmacokinetics, especially in pediatric population, therapeutic drug monitoring of voriconazole is essential to control fungal infection.