躯干脂肪与虚弱是肥胖老年人群认知表现的重要预测因子。
Truncal Fat and Frailty Are Important Predictors of Cognitive Performance among Aging Adults with Obesity.
机构信息
Dennis T. Villareal, MD, Baylor College of Medicine, Michael E DeBakey VA Medical Center, 2002 Holcombe Blvd, Houston TX, USA,
出版信息
J Nutr Health Aging. 2022;26(5):425-429. doi: 10.1007/s12603-022-1776-x.
OBJECTIVES
To explore associations among cognition, frailty, and obesity in older adults.
DESIGN
Descriptive, secondary analysis of baseline data from two related lifestyle intervention trials.
SETTING
Clinical study open to civilian population through the Center for Translational Research on Inflammatory Diseases at the Veterans Affairs Medical Center in Houston, TX.
PARTICIPANTS
One hundred eight community-dwelling adults with obesity, aged 65 or older, recruited consecutively from two lifestyle intervention trials.
MEASUREMENTS
Cognition was assessed using Composite Age-Adjusted Scale Score from the National Institutes of Health Toolbox Cognition Battery: Obesity was assessed by body mass index (BMI) and also by truncal fat mas via dual energy x-ray absorptiometry. Frailty was assessed using the Physical Performance Test.
RESULTS
A significant linear regression model for cognition revealed frailty as the strongest predictor, followed by sex, and then truncal fat (R2=0.340, p<0.001).
CONCLUSION
Cognition among community-dwelling older adults with obese BMI may worsen with greater truncal fat mass. Frailty appears to be an important predictor of cognitive performance in this population.
目的
探讨老年人认知、衰弱和肥胖之间的关联。
设计
对休斯顿得克萨斯州退伍军人事务医疗中心炎症性疾病转化研究中心两项相关生活方式干预试验的基线数据进行描述性、二次分析。
地点
通过得克萨斯州休斯顿退伍军人事务医疗中心炎症性疾病转化研究中心向普通人群开放的临床研究。
参与者
连续招募了来自两项生活方式干预试验的 108 名肥胖且年龄在 65 岁或以上的社区居住成年人。
测量
使用 NIH 工具箱认知电池的综合年龄调整量表评分评估认知：通过体重指数（BMI）和双能 X 射线吸收仪评估的躯干脂肪来评估肥胖。通过体能测试评估衰弱。
结果
认知的显著线性回归模型显示，衰弱是最强的预测因素，其次是性别，然后是躯干脂肪（R2=0.340，p<0.001）。
结论
肥胖 BMI 的社区居住老年人的认知能力可能会随着更多的躯干脂肪而恶化。衰弱似乎是该人群认知表现的一个重要预测因素。
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