Institute of Healthy Geography, School of Geography and Tourism, Shaanxi Normal University, 620 West Chang'an Street, Chang'an District, Xi'an 710119, China.
Institute of Healthy Geography, School of Geography and Tourism, Shaanxi Normal University, 620 West Chang'an Street, Chang'an District, Xi'an 710119, China.
Sci Total Environ. 2022 Sep 10;838(Pt 1):155962. doi: 10.1016/j.scitotenv.2022.155962. Epub 2022 May 16.
Blood lipid is an important factor affecting cardiovascular disease in middle-aged and elderly people. At present, the associations between environmental factors and blood lipid level in elderly people has been controversial, and the nonlinear effect of their relationship is lack of research.
This study used data from a national cross-sectional survey of blood lipid levels in 13,354 subjects and data from environmental monitoring sites. Logistic regression was used to measure the relationship between the basic characteristics of the study population and blood lipid levels. After controlling the confounding factors, the nonlinear associations between environmental factors and blood lipid levels of middle-aged and elderly people in different geographical regions were studied by random forest model.
The risk of dyslipidemia is significantly higher in middle-aged women, obese people, elderly people, and urban people. Smoking and alcohol consumption increase the risk. The associations between environmental factors and lipid levels of middle-aged and elderly people are nonlinear, the correlation effect between air pollutants and blood lipid level is mainly shown in northern China, and the correlation between meteorological factors and blood lipid level is more obvious in southern China.
This study shows that the associations between environmental factors and lipid levels in middle-aged and elderly population are nonlinear and have regional differences. Therefore it should be considered in optimizing the allocation of public health resources and preventing and controlling environmental exposure of middle-aged and elderly population.
血脂是影响中老年人心血管疾病的重要因素。目前，环境因素与老年人血脂水平之间的关系存在争议，且其关系的非线性效应缺乏研究。
本研究使用了来自全国血脂水平横断面调查的 13354 名受试者的数据和环境监测站点的数据。采用 Logistic 回归来衡量研究人群的基本特征与血脂水平之间的关系。在控制混杂因素后，通过随机森林模型研究了不同地理区域中老年人群环境因素与血脂水平之间的非线性关系。
中年女性、肥胖者、老年人和城市居民的血脂异常风险显著增加。吸烟和饮酒会增加风险。环境因素与中老年人血脂水平之间的关系是非线性的，在北方地区，空气污染物质与血脂水平之间的相关性主要表现为非线性，而在南方地区，气象因素与血脂水平之间的相关性更为明显。
本研究表明，中老年人环境因素与血脂水平之间的关系是非线性的，且存在地域差异。因此，在优化公共卫生资源配置和预防控制中老年人环境暴露方面应予以考虑。
