Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark.
Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Neurosci Biobehav Rev. 2022 Jul;138:104689. doi: 10.1016/j.neubiorev.2022.104689. Epub 2022 May 16.
Clinical research into serotonergic psychedelics is expanding rapidly, showing promising efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs-fMRI) is a commonly used strategy to identify psychedelic-induced changes in neural pathways in clinical and healthy populations. Here we, a large group of psychedelic imaging researchers, review the 42 research articles published to date, based on the 17 unique studies evaluating psychedelic effects on rs-fMRI, focusing on methodological variation. Prominently, we observe that nearly all studies vary in data processing and analysis methodology, two datasets are the foundation of over half of the published literature, and there is lexical ambiguity in common outcome metric terminology. We offer guidelines for future studies that encourage coherence in the field. Psychedelic rs-fMRI will benefit from the development of novel methods that expand our understanding of the brain mechanisms mediating its intriguing effects; yet, this field is at a crossroads where we must also consider the critical importance of consistency and replicability to effectively converge on stable representations of the neural effects of psychedelics.
血清素能致幻剂的临床研究正在迅速扩展，在众多疾病中显示出有希望的疗效。静息态功能磁共振成像(rs-fMRI)是一种常用的策略，可用于识别临床和健康人群中致幻剂诱导的神经通路变化。在这里，我们是一群大型的迷幻成像研究人员，基于 17 项独特的研究，对迄今为止发表的 42 篇研究文章进行了综述，重点是方法学的变化。值得注意的是，我们观察到几乎所有的研究在数据处理和分析方法上都存在差异，两个数据集是超过一半已发表文献的基础，并且常用的结果指标术语存在词汇歧义。我们为未来的研究提供了指导方针，鼓励该领域的一致性。迷幻 rs-fMRI 将受益于新方法的发展，这些方法将扩展我们对介导其有趣效应的大脑机制的理解；然而，该领域正处于十字路口，我们还必须考虑一致性和可重复性的重要性，以有效地收敛于迷幻药物的神经效应的稳定表示。
