Svensson Lars G
Department of Thoracic and Cardiovascular Surgery, Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
J Thorac Cardiovasc Surg. 2023 May;165(5):1754-1758. doi: 10.1016/j.jtcvs.2022.03.026. Epub 2022 May 16.
Managing patients with thoracoabdominal aneurysms is demanding yet fascinating, and requires a team effort. This invited talk presents lessons learned as our history with open and endovascular procedures evolved for 2578 descending and thoracoabdominal repairs over the past 20 years.
Beginning in 1985 with an analysis of 596 traumatic aortic ruptures and the risk of spinal cord ischemia, the evolution of research and procedures for thoracoabdominal aneurysms progressed. The focus of these studies, medication trials, and procedure adjustments was on lowering the risk of spinal cord ischemia.
Between January 2002 and December 2021, 2578 aneurysm repairs were performed. The respective mortality rates were 6.8% and 4.0% for all patients treated. The permanent spinal cord ischemia rates were 1.3% for open descending thoracic aortas and 4.9% for open thoracoabdominal aneurysms. A detailed analysis of open and thoracoabdominal repairs showed better long-term outcomes with open repairs.
Through multiple randomized trials and innovations with procedures and techniques, the risk of death and spinal cord ischemia have been reduced. Long-term survival has also been improved. The pursuit of reducing the risks of descending and ascending thoracoabdominal repairs is a fascinating endeavor that has resulted in better patient outcomes. Nevertheless, this is a journey, and there will always be more room to achieve even better results.
管理胸腹主动脉瘤患者既具挑战性又饶有趣味,且需要团队协作。本次特邀演讲介绍了我们在过去20年中对2578例降主动脉和胸腹主动脉修复术进行开放手术和血管内手术的过程中所吸取的经验教训。
从1985年对596例创伤性主动脉破裂及脊髓缺血风险进行分析开始,胸腹主动脉瘤的研究和手术不断发展。这些研究、药物试验及手术调整的重点是降低脊髓缺血风险。
2002年1月至2021年12月期间,共进行了2578例动脉瘤修复术。所有接受治疗患者的死亡率分别为6.8%和4.0%。开放降胸主动脉手术的永久性脊髓缺血率为1.3%,开放胸腹主动脉瘤手术的永久性脊髓缺血率为4.9%。对开放手术和胸腹主动脉修复术的详细分析显示,开放手术的长期效果更好。
通过多项随机试验以及手术和技术创新,死亡风险和脊髓缺血风险得以降低,长期生存率也有所提高。降低降主动脉和胸腹主动脉修复术风险的追求是一项引人入胜的努力,已为患者带来了更好的结果。然而,这是一个持续的过程,仍有很大空间可实现更优的结果。