University School of Management and Entrepreneurship, Delhi Technological University, East Delhi Campus, Room No. 305, Vivek Vihar Phase II, Delhi, 110095, India.
Int J Clin Oncol. 2022 Aug;27(8):1309-1320. doi: 10.1007/s10147-022-02182-0. Epub 2022 May 20.
This study examines the burden of colorectal cancer (CRC) in European Union (EU) countries in the last 3 decades.
The data pertaining to CRC burden were procured from the Global Burden of Disease 2019 Study for 28 EU countries (including United Kingdom) for the period 1990-2019. The age-standardized rates of CRC were utilized to compare the country-wise burden and joinpoint regression models were applied to examine the trends.
In EU, CRC incident cases increased by 70.2% from 261,306 to 444,872 and deaths increased by 36.8% from 155,823 to 213,174 between 1990 and 2019. The age-standardized incidence rate (ASIR) increased by 11.9% from 37.8/100,000 to 42.3/100,000 between 1990 and 2019; in contrast, the age-standardized mortality rate (ASMR) decreased by 16.9% (1990: 22.4/100,000; 2019: 18.6/100,000) and age-standardized DALYs rate (ASDALR) decreased by 18.6% (1990: 472.9/100,000; 2019: 385.1/100,000) in the study period. In 2019, Hungary was the leading country in terms of ASMR (28.6/100,000) and ASDALR (630.3/100,000), and Lithuania (29.2/100,000) had the lowest ASIR, whereas Finland had the lowest ASMR (12.3/100,000) and ASDALR (253.6/100,000) in 2019.
CRC incidence is increasing in EU and mortality rates, although decreasing, are still unacceptably high. CRC control efforts must be focused around early detection using screening and prevention through reduction of modifiable risk factors. Increasing CRC incidence rates in young adults in recent years requires more research to pinpoint risk factors, and there must be more awareness of this recent development among general public and clinicians.
本研究旨在考察过去 30 年欧盟（EU）国家结直肠癌（CRC）的负担情况。
本研究从 2019 年全球疾病负担研究中获取了 28 个欧盟国家（包括英国）的 CRC 负担数据，时间范围为 1990 年至 2019 年。本研究使用年龄标准化率（ASR）来比较各国的负担情况，并应用 joinpoint 回归模型来检测趋势。
在欧盟，CRC 的发病例数从 1990 年的 261306 例增加到 2019 年的 444872 例，增加了 70.2%；死亡例数从 1990 年的 155823 例增加到 2019 年的 213174 例，增加了 36.8%。1990 年至 2019 年期间，CRC 的年龄标准化发病率（ASIR）从 37.8/100000 增加到 42.3/100000，增加了 11.9%；相比之下，年龄标准化死亡率（ASMR）下降了 16.9%（1990 年：22.4/100000；2019 年：18.6/100000），年龄标准化伤残调整生命年率（ASDALR）下降了 18.6%（1990 年：472.9/100000；2019 年：385.1/100000）。2019 年，匈牙利的 ASMR（28.6/100000）和 ASDALR（630.3/100000）最高，立陶宛的 ASIR 最低（29.2/100000），而芬兰的 ASMR（12.3/100000）和 ASDALR（253.6/100000）最低。
欧盟的 CRC 发病率在增加，尽管死亡率在下降，但仍处于不可接受的高水平。CRC 控制工作必须集中在早期发现，通过筛查和预防来降低可改变的危险因素。近年来，年轻成年人 CRC 发病率的上升需要更多的研究来确定危险因素，普通民众和临床医生必须更加关注这一最新发展。
