Institute of Biomedical Sciences, Shanxi University, Taiyuan, 030006, China.
Med Oncol. 2023 Aug 2;40(9):259. doi: 10.1007/s12032-023-02131-5.
lncRNAs play a vital part in cancer development by regulating gene expression. Among these, the lncRNA HOTAIR has gained considerable attention due to its entanglement in multiple cellular processes, including chromatin remodeling and gene regulation. HOTAIR has a complex structure consisting of multiple domains that interact with various protein complexes and RNA molecules. In colorectal cancer (CRC), HOTAIR expression is upregulated, and its overexpression has been correlated with poor patient prognosis and resistance to chemotherapy. HOTAIR has been found to regulate gene expression and promote cancer growth by interacting with specific miRNAs. In addition, HOTAIR has been implicated in the development of treatment resistance in colorectal cancer. To develop effective treatments, it's important to understand how HOTAIR regulates gene expression. This article discusses HOTAIR's structure, functions, and mechanisms in CRC and its potential as a target for therapy. The author also suggests future research directions to better understand HOTAIR's role in CRC progression and drug resistance.
lncRNAs 通过调节基因表达在癌症发展中起着至关重要的作用。在这些 lncRNAs 中，lncRNA HOTAIR 因其参与多种细胞过程而引起了相当大的关注，包括染色质重塑和基因调控。HOTAIR 具有复杂的结构，由多个与各种蛋白质复合物和 RNA 分子相互作用的结构域组成。在结直肠癌 (CRC) 中，HOTAIR 的表达上调，其过表达与患者预后不良和对化疗的耐药性相关。已经发现 HOTAIR 通过与特定的 miRNAs 相互作用来调节基因表达并促进癌症生长。此外，HOTAIR 与结直肠癌治疗耐药性的发展有关。为了开发有效的治疗方法，了解 HOTAIR 如何调节基因表达非常重要。本文讨论了 HOTAIR 在 CRC 中的结构、功能和机制及其作为治疗靶点的潜力。作者还提出了未来的研究方向，以更好地了解 HOTAIR 在 CRC 进展和耐药性中的作用。
