Sawada Toshiki, Kang Sungmin, Watanabe Junji, Mihara Hisakazu, Serizawa Takeshi
Department of Organic and Polymeric Materials, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.
Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B40 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
ACS Macro Lett. 2014 Apr 15;3(4):341-345. doi: 10.1021/mz500073t. Epub 2014 Mar 24.
Novel hybrid hydrogels composed of tag-peptides (antigens) displaying filamentous viruses and antibody-immobilized gold nanoparticles (GNPs) through specific interactions between the two components were constructed. The strength of the antigen-antibody interactions greatly affected the macroscopic mechanical properties. The phages and the GNPs in the hydrogels formed lyotropic liquid crystals and well-ordered network structures, respectively. It was suggested that the structurally much different components were cooperatively assembled into the highly regular structures through time-dependent cross-linking processes. This hybrid hydrogel of visible and huge components will open attractive opportunities for the science and technology of next-generation soft materials.
构建了一种新型杂化水凝胶，其由展示丝状病毒的标签肽（抗原）和通过两种组分之间的特异性相互作用固定抗体的金纳米颗粒（GNP）组成。抗原 - 抗体相互作用的强度极大地影响了宏观力学性能。水凝胶中的噬菌体和GNP分别形成溶致液晶和有序的网络结构。研究表明，结构差异很大的组分通过时间依赖性交联过程协同组装成高度规则的结构。这种由可见且巨大的组分组成的杂化水凝胶将为下一代软材料的科学技术带来诱人的机遇。
