Zachary L S, Smith D J, Heggers J P, Robson M C, Boertman J A, Niu X T, Schileru R E, Sacks R J
J Hand Surg Am. 1987 Mar;12(2):240-5. doi: 10.1016/s0363-5023(87)80279-4.
Inadvertent intra-arterial injection of drugs produces a well-defined clinical syndrome whose pathophysiology remains unclear. This study was designed to determine the role of the inflammatory mediator, thromboxane, in intra-arterial drug injections. The rabbit ear model, as described by Kinmonth and Sheppard, was used. Five of the experimental groups were treated with specific or nonspecific thromboxane blocking agents and two groups served as controls. Immunohistochemical staining of the control ears showed elevated levels of thromboxane within the first 6 hours postinjury. The specific thromboxane blocking agents, methimazole and Aloe vera, showed almost complete blockade of thromboxane production. The percentage of ear survival was significantly greater in the group treated with topical Aloe vera (p less than 0.05) and even greater survival was achieved in the combined Aloe vera/methimazole group (p less than 0.01). On the basis of these results, we have begun treatment of such injuries with specific and nonspecific thromboxane blocking agents.
药物意外动脉内注射会产生一种明确的临床综合征，但其病理生理学仍不清楚。本研究旨在确定炎症介质血栓素在动脉内药物注射中的作用。采用了金蒙特和谢泼德描述的兔耳模型。五个实验组用特异性或非特异性血栓素阻断剂进行治疗，两组作为对照。对照耳的免疫组织化学染色显示，损伤后6小时内血栓素水平升高。特异性血栓素阻断剂甲巯咪唑和芦荟几乎完全阻断了血栓素的产生。局部应用芦荟治疗组的耳部存活率显著更高（p小于0.05），芦荟/甲巯咪唑联合治疗组的存活率更高（p小于0.01）。基于这些结果，我们已开始用特异性和非特异性血栓素阻断剂治疗此类损伤。
