通过水相单电子转移活性自由基聚合合成及聚集双亲水性二嵌段糖聚合物
Synthesis and Aggregation of Double Hydrophilic Diblock Glycopolymers via Aqueous SET-LRP.
作者信息
Zhang Qiang, Wilson Paul, Anastasaki Athina, McHale Ronan, Haddleton David M
机构信息
Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia.
出版信息
ACS Macro Lett. 2014 May 20;3(5):491-495. doi: 10.1021/mz5001724. Epub 2014 May 9.
A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of -isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive double hydrophilic diblock glycopolymers which revealed self-assembly properties in aqueous solution forming well-defined, sugar-decorated nanoparticles.
合成了一种化学未保护的含甘露糖丙烯酸酯（ManA）单体，并通过铜（0）介导的水相自由基聚合（SET-LRP）进行聚合。加入N-异丙基丙烯酰胺（NIPAm）或二乙二醇乙醚丙烯酸酯（DEGEEA）溶液后，实现了一锅法嵌段共聚，形成了热响应性双亲水二嵌段糖聚合物，该聚合物在水溶液中表现出自组装特性，形成了定义明确的、糖修饰的纳米颗粒。
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