Leff J P, Tress K H
Int Clin Psychopharmacol. 1986 Jul;1 Suppl 1:27-40.
A group of 13 untreated schizophrenic patients was collected over two and a half years. They were prescribed a standard regime of oral haloperidol, and where possible were transferred to haloperidol decanoate depot injections when their clinical condition stabilised. The progress of their symptoms was monitored weekly with a modification of the Present State Examination called the PSE Change Rating Scale. The ratings demonstrated a surprisingly good response to neuroleptic treatment in these chronic patients. Ten out of the 13 reached an arbitrary criterion of improvement with respect to psychotic symptoms, and in six patients these disappeared entirely. The reasons why the patients remained untreated for so long are considered, and include vagrancy, living with high Expressed Emotion relatives, and neglect in the community.
在两年半的时间里收集了一组13名未经治疗的精神分裂症患者。他们被给予口服氟哌啶醇的标准治疗方案，并在临床状况稳定时尽可能转为氟哌啶醇癸酸酯长效注射剂治疗。使用一种名为PSE变化评定量表的改良版现况检查，每周监测他们症状的进展情况。评定结果显示，这些慢性患者对抗精神病药物治疗的反应出奇地好。13名患者中有10名在精神病症状方面达到了任意设定的改善标准，6名患者的症状完全消失。文中还探讨了这些患者长期未接受治疗的原因，包括流浪、与高情感表达亲属同住以及社区忽视等情况。
