Sweet's Syndrome Accompanied by Coinfection with Multiple Pathogens and Disseminated Infection Presenting with Osteolytic Destruction During 12 Years of Follow-Up: A Rare Case Report.

BACKGROUND

Anti-IFN-γ autoantibodies (AIGAs) are closely related to the disseminated infection of multiple pathogens. (M. phlei) is a nonpathogenic nontuberculous mycobacteria (NTM), and infection of the bone is extremely rare. We report a rare case of high-titer AIGAs presenting with Sweet's syndrome (SS) accompanied by opportunistic coinfection with multiple pathogens during 12 years of follow-up. The patient in this case also developed disseminated infection with osteolytic destruction after treatment for SS.

CASE PRESENTATION

A 68-year-old Chinese woman was admitted to our hospital in August 2009 due to fever and cough with expectoration for 3 months. The patient was successively infected with , herpes zoster virus and . Chest computed tomography (CT) showed recurrent consolidations in different lung fields. After 15 months of antimicrobial treatment, the patient experienced partial recovery. In September 2010, the patient was pathologically diagnosed with SS due to the presence of multiple rashes. After prednisone and thalidomide treatment, the rashes subsided, and the pulmonary lesions had completely absorbed. In May 2011, the patient was diagnosed with disseminated tuberculosis and was administered anti-tuberculosis therapy for 3 months without improvement. NTM was subsequently cultured from her sputum and chest wall pus, and she improved after 20 months of anti-NTM therapy. In March 2016, the patient developed osteolytic destruction of the C7-T2 vertebral bodies with a back abscess. NTM was eventually cultured from the dorsal abscess pus and further identified as . High-titer AIGAs were detected in the patient's serum. After another round of aggressive anti-NTM therapy, the patient was finally cured.

CONCLUSION

Patients with AIGA-associated anti-cytokine autoantibody disease can present with multiple opportunistic infections and SS involving the lung. AIGA-associated immunodeficiency leads to infection with nonpathogenic , which is refractory, can cause relapse, and even leads to osteolytic destruction.